{"ATC Code":"N01AX13","Abbreviation":"Nitrous","Aliases":["Laughing gas","Dinitrogen oxide","Dinitrogen monoxide","Factitious air","nitrogen protoxide","Nitrogen oxide (N2O)","Nitrogen hypoxide","Hyponitrous acid anhydride","Stickdioxyd","oxyde nitreux"],"Boiling Point":"-129.1 °F at 760 mmHg (USCG, 1999)","CAS":"10024-97-2","ChEBI":"CHEBI:17045","ChEMBL":"CHEMBL1234579","Chirality":"achiral","Color/Form":"Colorless gas [Note: Shipped as a liquified compressed gas]","Decomposition":"This compound decomposes explosively at high temperatures.","Density":"1.266 at -128.2 °F (USCG, 1999) - Denser than water; will sink g/cm\u003csup\u003e3\u003c/sup\u003e","Dosing Info":[],"Drug Classes":"Breast Feeding; Lactation; Milk, Human; Anesthetics, Inhalation","Drug Indication":"Sedation","Drug Warnings":"A 65 year-old man with no medical history, presented problems walking and memory loss 16 days after surgery for femoral prosthesis. Neurological examination revealed paraplegia with syndrome of combined degeneration of the spinal cord. The exploration of cognitive functions showed disorientation in time with memory disorders and disturbance of executive functioning. There was no apraxia, aphasia or agnosia. There were neither psychotic symptoms nor mood changes. ... Red blood count revealed an anemia with macrocytosis (MCV=120 3). Vitamin B12 rate was very low. Folate blood level was normal. Brain MRI showed moderate cerebral atrophy. Other investigations led to the diagnosis of Biermer's disease (fundic atrophy at biopsy with presence in the serum of antibodies to intrinsic factor). The diagnosis of neurological attack related to a vitamin B12 deficiency secondary to Biermer's disease was established, but the appearance of disorders in the post-operative period suggested the existence of an added factor. ... Anesthesia was maintained by nitrous oxide during two hours and the patient exhibited pre-operative anemia with macrocytosis. The hypothesis of decompensation of latent vitamin B12 deficiency by nitrous oxide was evoked. Replacement therapy by vitamin B12 induced real improvement of the cognitive impairment...","DrugClasses":["opioid"],"European Community (EC) Number":"233-032-0","Human Drugs":"Breast Feeding; Lactation; Milk, Human; Anesthetics, Inhalation","IUPACName":"nitrous oxide","InChI":"InChI=1S/N2O/c1-2-3","InChIKey":"GQPLMRYTRLFLPF-UHFFFAOYSA-N","MeSH Pharmacological Classification":"A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)","Melting Point":"-131.5 °F (USCG, 1999)","MolecularFormula":"N\u003csub\u003e2\u003c/sub\u003eO","MolecularWeight":"44.013 g/mol","Odor":"Slightly sweetish","Physical Description":"Nitrous oxide is a colorless, sweet-tasting gas. It is also known as \"laughing gas\". Continued breathing of the vapors may impair the decision making process. It is noncombustible but it will accelerate the burning of combustible material in a fire. It is soluble in water. Its vapors are heavier than air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. It is used as an anesthetic, in pressure packaging, and to manufacture other chemicals.","PubChemId":948,"Record Description":["Nitrous Oxide can cause developmental toxicity and female reproductive toxicity according to The National Institute for Occupational Safety and Health (NIOSH).","Nitrous oxide is a colorless, sweet-tasting gas. It is also known as \"laughing gas\". Continued breathing of the vapors may impair the decision making process. It is noncombustible but it will accelerate the burning of combustible material in a fire. It is soluble in water. Its vapors are heavier than air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. It is used as an anesthetic, in pressure packaging, and to manufacture other chemicals.","Nitrous oxide, refrigerated liquid appears as a colorless liquid. Density 1.22 g / cm3 at its boiling point of -89 °C. Boils to give a colorless gas that is sweet-smelling and moderately toxic. The gas has narcotic effects when inhaled (laughing gas). Shipped under refrigeration. Vapor pressure is at about 745 psig at 70 °F. Used to freeze foods and to manufacture other chemicals.","Dinitrogen oxide is a nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream. It has a role as an inhalation anaesthetic, a NMDA receptor antagonist, a bacterial metabolite, a general anaesthetic, a vasodilator agent, an analgesic, a member of greenhouse gas, a raising agent, a member of food packaging gas, a food propellant and a refrigerant. It is a nitrogen oxide and a gas molecular entity.","Nitrous oxide, commonly known as \"laughing gas\", is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as \"laughing gas\" due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug.","Nitrous oxide is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).","Nitrous Oxide is a naturally occurring gas that is colorless and non flammable. It can be manufactured and used for a variety of things such as a pharmacologic agent to produce anesthesia, a food additive as a propellant, and an additive to fuels to increase available oxygen in combustion.","NITROUS OXIDE is a small molecule drug with a maximum clinical trial phase of IV (across all indications) and has 16 investigational indications.","Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.","See also:  ... View More ...","Nitrous Oxide can cause developmental toxicity and female reproductive toxicity according to The National Institute for Occupational Safety and Health (NIOSH).","Dinitrogen oxide is a nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream. It has a role as an inhalation anaesthetic, a NMDA receptor antagonist, a bacterial metabolite, a general anaesthetic, a vasodilator agent, an analgesic, a member of greenhouse gas, a raising agent, a member of food packaging gas, a food propellant and a refrigerant. It is a nitrogen oxide and a gas molecular entity."],"References":[{"name":"Wikipedia","url":"https://en.wikipedia.org/wiki/Nitrous oxide"},{"name":"Wikidata","url":"https://www.wikidata.org/wiki/Q905750"},{"name":"DrugBank","url":"https://go.drugbank.com/drugs/DB06690"},{"name":"PubChem","url":"https://pubchem.ncbi.nlm.nih.gov/compound/948"},{"name":"ChemSpider","url":"https://www.chemspider.com/Chemical-Structure.923.html"},{"name":"ChEMBL","url":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1234579"},{"name":"ChEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17045"},{"name":"Common Chemistry","url":"https://commonchemistry.cas.org/detail?cas_rn=10024-97-2"},{"name":"HMDB","url":"https://hmdb.ca/metabolites/HMDB0035807"},{"name":"KEGG","url":"https://www.kegg.jp/entry/C00887"},{"name":"UNII","url":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/K50XQU1029"},{"name":"EPA DSSTox","url":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021066"}],"Reported Fatal Dose":"Lethal nitrous oxide blood level 350 mg/L, 35 mg/dL","SMILES":"[N-]=[N+]=O","Solubility":"0.1 % at 77 °F (NIOSH, 2024)","Stability/Shelf Life":"Stable under recommended storage conditions.","StructureBase64":"PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHhtbG5zOnhsaW5rPSJodHRwOi8vd3d3LnczLm9yZy8xOTk5L3hsaW5rIiBoZWlnaHQ9IjIxLjMzMW1tIiB2ZXJzaW9uPSIxLjIiIHZpZXdCb3g9IjAgMCAzNC4yMSAyMS4zMzEiIHdpZHRoPSIzNC4yMW1tIj4KICAgICAgCiAgICA8ZGVzYz5HZW5lcmF0ZWQgYnkgdGhlIENoZW1pc3RyeSBEZXZlbG9wbWVudCBLaXQgKGh0dHA6Ly9naXRodWIuY29tL2Nkayk8L2Rlc2M+CiAgICAgIAogICAgPGcgZmlsbD0iIzMwNTBGOCIgc3Ryb2tlPSIjMDAwMDAwIiBzdHJva2UtbGluZWNhcD0icm91bmQiIHN0cm9rZS1saW5lam9pbj0icm91bmQiIHN0cm9rZS13aWR0aD0iLjciPgogICAgICAgICAgICAKICAgICAgICA8cmVjdCBmaWxsPSIjRkZGRkZGIiBoZWlnaHQ9IjIyLjAiIHN0cm9rZT0ibm9uZSIgd2lkdGg9IjM1LjAiIHg9Ii4wIiB5PSIuMCIvPgogICAgICAgICAgICAKICAgICAgICA8ZyBjbGFzcz0ibW9sIiBpZD0ibW9sMSI+CiAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICA8ZyBjbGFzcz0iYm9uZCIgaWQ9Im1vbDFibmQxIj4KICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICA8bGluZSB4MT0iNy41MzgiIHgyPSIxNC40MyIgeTE9IjE1LjQ0NSIgeTI9IjExLjQ2NiIvPgogICAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgICAgIDxsaW5lIHgxPSI4Ljc1OCIgeDI9IjE1LjY0OSIgeTE9IjE3LjU1NiIgeTI9IjEzLjU3OCIvPgogICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICA8bGluZSBjbGFzcz0iaGkiIHN0cm9rZT0iIzMwNTBGOCIgeDE9IjcuNTM4IiB4Mj0iMTAuOTg0IiB5MT0iMTUuNDQ1IiB5Mj0iMTMuNDU1NSIvPgogICAgICAgICAgICAgICAgPGxpbmUgY2xhc3M9ImhpIiBzdHJva2U9IiMzMDUwRjgiIHgxPSI3LjUzOCIgeDI9IjEwLjk4NCIgeTE9IjE1LjQ0NSIgeTI9IjEzLjQ1NTUiLz4KICAgICAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJoaSIgc3Ryb2tlPSIjMzA1MEY4IiB4MT0iMTQuNDMiIHgyPSIxMC45ODQiIHkxPSIxMS40NjYiIHkyPSIxMy40NTU1Ii8+CiAgICAgICAgICAgICAgICA8bGluZSBjbGFzcz0iaGkiIHN0cm9rZT0iIzMwNTBGOCIgeDE9IjguNzU4IiB4Mj0iMTIuMjAzNDk5OTk5OTk5OTk4IiB5MT0iMTcuNTU2IiB5Mj0iMTUuNTY3Ii8+CiAgICAgICAgICAgICAgICA8bGluZSBjbGFzcz0iaGkiIHN0cm9rZT0iIzMwNTBGOCIgeDE9IjguNzU4IiB4Mj0iMTIuMjAzNDk5OTk5OTk5OTk4IiB5MT0iMTcuNTU2IiB5Mj0iMTUuNTY3Ii8+CiAgICAgICAgICAgICAgICA8bGluZSBjbGFzcz0iaGkiIHN0cm9rZT0iIzMwNTBGOCIgeDE9IjE1LjY0OSIgeDI9IjEyLjIwMzQ5OTk5OTk5OTk5OCIgeTE9IjEzLjU3OCIgeTI9IjE1LjU2NyIvPgogICAgICAgICAgICA8L2c+CiAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICA8ZyBjbGFzcz0iYm9uZCIgaWQ9Im1vbDFibmQyIj4KICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICA8bGluZSB4MT0iMjMuMjMxIiB4Mj0iMjcuNTAxIiB5MT0iNi4zODUiIHkyPSIzLjkyIi8+CiAgICAgICAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICAgICAgPGxpbmUgeDE9IjI0LjQ1IiB4Mj0iMjguNzIiIHkxPSI4LjQ5NiIgeTI9IjYuMDMxIi8+CiAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJoaSIgc3Ryb2tlPSIjMzA1MEY4IiB4MT0iMjMuMjMxIiB4Mj0iMjUuMzY2IiB5MT0iNi4zODUiIHkyPSI1LjE1MjUiLz4KICAgICAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJoaSIgc3Ryb2tlPSIjMzA1MEY4IiB4MT0iMjMuMjMxIiB4Mj0iMjUuMzY2IiB5MT0iNi4zODUiIHkyPSI1LjE1MjUiLz4KICAgICAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJoaSIgc3Ryb2tlPSIjRkYwRDBEIiB4MT0iMjcuNTAxIiB4Mj0iMjUuMzY2IiB5MT0iMy45MiIgeTI9IjUuMTUyNSIvPgogICAgICAgICAgICAgICAgPGxpbmUgY2xhc3M9ImhpIiBzdHJva2U9IiMzMDUwRjgiIHgxPSIyNC40NSIgeDI9IjI2LjU4NSIgeTE9IjguNDk2IiB5Mj0iNy4yNjM1MDAwMDAwMDAwMDA1Ii8+CiAgICAgICAgICAgICAgICA8bGluZSBjbGFzcz0iaGkiIHN0cm9rZT0iIzMwNTBGOCIgeDE9IjI0LjQ1IiB4Mj0iMjYuNTg1IiB5MT0iOC40OTYiIHkyPSI3LjI2MzUwMDAwMDAwMDAwMDUiLz4KICAgICAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJoaSIgc3Ryb2tlPSIjRkYwRDBEIiB4MT0iMjguNzIiIHgyPSIyNi41ODUiIHkxPSI2LjAzMSIgeTI9IjcuMjYzNTAwMDAwMDAwMDAwNSIvPgogICAgICAgICAgICA8L2c+CiAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICA8ZyBjbGFzcz0iYXRvbSIgaWQ9Im1vbDFhdG0xIj4KICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICA8cGF0aCBkPSJNNi45MzUgMjAuNzcxaC0uNzJsLTIuNjE5IC00LjA2NmgtLjAzcS4wMTIgLjIzOCAuMDMgLjU5NXEuMDI0IC4zNTcgLjAyNCAuNzMydjIuNzM5aC0uNTY2di00LjloLjcxNGwyLjYwOCA0LjA1NWguMDNxLS4wMDYgLS4xMDggLS4wMTggLS4zMjhxLS4wMTIgLS4yMiAtLjAyNCAtLjQ3NnEtLjAwNiAtLjI2MiAtLjAwNiAtLjQ4MnYtMi43NjloLjU3N3Y0Ljl6IiBzdHJva2U9Im5vbmUiLz4KICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICA8cGF0aCBkPSJNMi40OTIgMTUuNzI1di4yOTNoLTEuOTMydi0uMjkzaDEuOTMyeiIgc3Ryb2tlPSJub25lIi8+CiAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPC9nPgogICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPGcgY2xhc3M9ImF0b20iIGlkPSJtb2wxYXRtMiI+CiAgICAgICAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICAgICAgPHBhdGggZD0iTTIwLjEzNCAxMy4xNTFoLS43MjFsLTIuNjE5IC00LjA2NmgtLjAzcS4wMTIgLjIzOCAuMDMgLjU5NXEuMDI0IC4zNTcgLjAyNCAuNzMydjIuNzM5aC0uNTY2di00LjloLjcxNWwyLjYwNyA0LjA1NWguMDNxLS4wMDYgLS4xMDggLS4wMTggLS4zMjhxLS4wMTIgLS4yMiAtLjAyNCAtLjQ3NnEtLjAwNiAtLjI2MiAtLjAwNiAtLjQ4MnYtMi43NjloLjU3OHY0Ljl6IiBzdHJva2U9Im5vbmUiLz4KICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICA8cGF0aCBkPSJNMjEuODEgOC4xMDdoLjgxOHYuMjkzaC0uODE4di44NDZoLS4yOTd2LS44NDZoLS44MTh2LS4yOTNoLjgxOHYtLjg1aC4yOTd2Ljg1eiIgc3Ryb2tlPSJub25lIi8+CiAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPC9nPgogICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPHBhdGggY2xhc3M9ImF0b20iIGQ9Ik0zMy42NSAzLjA3OHEuMCAuNzU2IC0uMjU2IDEuMzI4cS0uMjU2IC41NjUgLS43NTYgLjg4MXEtLjUgLjMxNSAtMS4yNDQgLjMxNXEtLjc1NiAuMCAtMS4yNjIgLS4zMTVxLS41MDYgLS4zMTYgLS43NTYgLS44ODdxLS4yNDQgLS41NzIgLS4yNDQgLTEuMzM0cS4wIC0uNzUgLjI0NCAtMS4zMDlxLjI1IC0uNTY2IC43NTYgLS44ODFxLjUwNiAtLjMxNiAxLjI3NCAtLjMxNnEuNzMyIC0uMCAxLjIzMiAuMzE2cS41IC4zMDkgLjc1NiAuODc1cS4yNTYgLjU2NSAuMjU2IDEuMzI3ek0yOS43ODcgMy4wNzhxLS4wIC45MjMgLjM4NyAxLjQ1OXEuMzkzIC41MyAxLjIyIC41M3EuODQg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sweetish","Therapeutic Uses":"Analgesics, Non-Narcotic; Anesthetics, Inhalation","Title":"Nitrous oxide","UNII":"K50XQU1029","Wikidata":"Q905750","XLogP":0.5}